Janssen Research & Development, L.L.C., a division of Johnson & Johnson’s Family of Companies is recruiting for a Scientist, Neuropharmacology located in San Diego, CA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
We are seeking a highly motivated PhD-level Scientist with experience in ion channel pharmacology to join our Lead Evaluation and Cellular Pharmacology (LECP) team in La Jolla. LECP plays a critical role within the larger Therapeutics Discovery organization, striving to deliver high-quality chemical leads and clinical compounds for all five Therapeutic Areas of Janssen R&D. In this position, the Scientist is expected to spend the bulk of their time in the lab, designing and running electrophysiology-based assays, in addition to analyzing and accurately reporting data.
Qualified candidates should be motivated to generate and share results, enjoy working closely with other co-workers, both inside and outside LECP, and willing to balance their efforts between unique projects. Beyond general scientific acuity, the job duties of the Scientist will depend upon a comprehensive understanding of medium/high-throughput screening, patch-clamp recordings, and data reporting software. Accordingly, it is crucial that they display enthusiasm to learn and become proficient in any areas where their prior experience is limited.
Key Responsibilities:
- Conceive of and implement hit-finding plans for high-throughput screening (HTS) campaigns, in collaboration with therapeutic area partners and chemistry teams.
- Implement and troubleshoot weekly assays in support of medicinal chemistry efforts, assuring high-quality data analysis and reporting.
- Exhibit an awareness of new technological advances and biological insights, such that they are applied to assays in the laboratory.
- Thoughtfully integrate methodology details and results to prepare compelling scientific presentations for internal and external meetings.
Qualifications
Education:
- PhD in Neuroscience or a related field (e.g. Physiology, Pharmacology), with a minimum of 2 years of post-doctoral experience.
Experience and Skills:
Required:
- Proficiency performing and analyzing manual and/or automated patch-clamp electrophysiology experiments is required.
- Strong understanding of ion channel gating and membrane receptor pharmacology is required.
- Mammalian or neuronal cell culture; ability to maintain multiple cell lines is required.
- Proven analytical and problem-solving skills, along with proficiency using standard scientific software (e.g. Prism, Excel) is required.
- Excellent writing skills: preparation of experimental records and a track record of peer-reviewed publications is required.
- Strong oral communication skills and willingness to regularly present results to multidisciplinary project teams is required.
- Flexibility to shift focus between multiple projects on a daily/weekly basis is required.
Preferred:
- Experience mentoring and supervising non-PhD level scientists is preferred.
- Practical knowledge of medium/high throughput cell-based assays, including development, implementation, and troubleshooting is preferred.
- Familiarity with assay automation and miniaturization is preferred.
- Experience working on small-molecule drug discovery campaigns is preferred.
- Detailed knowledge of the patch-clamp method, as well as factors contributing to success in manual or automated patch-clamp experiments is preferred.
The anticipated base pay range for this position is $102,000 to $163,300.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.
